Obesity alters the gustatory perception of lipids in the mouse: plausible involvement of lingual CD36.

ABSTRACT: A relationship between orosensory detection of dietary lipids, regulation of fat intake, and body mass index was recently suggested. However, involved mechanisms are poorly understood. Moreover, whether obesity can directly modulate preference for fatty foods remains unknown. To address this question, exploration of the oral lipid sensing system was undertaken in diet-induced obese (DIO) mice. By using a combination of biochemical, physiological, and behavioral approaches, we found that i) the attraction for lipids is decreased in obese mice, ii) this behavioral change has an orosensory origin, iii) it is reversed in calorie-restricted DIO mice, revealing an inverse correlation between fat preference and adipose tissue size, iv) obesity suppresses the lipid-mediated downregulation of the l

SUBMITTER: Chevrot M 

PROVIDER: S-EPMC3735945 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature