Obesity-associated genetic variants in young Asian Indians with the metabolic syndrome and myocardial infarction.

ABSTRACT:

Objective

Associations between obesity-related polymorphisms and the metabolic syndrome in 485 young ( ≤ 45 Years) Asian Indian patients with acute myocardial infarction (AMI), and 300 matched controls were assessed.

Methods

Genetic variants included the adiponectin 45T→G and 276G→T, LEPR K109R and Q223R, MC4R-associated C→T and FTO A→T polymorphisms.

Results

The metabolic syndrome, as defined by NCEP ATP III and IDF criteria, was diagnosed in 61 and 60% of patients, respectively. No relationship was found between the obesity-associated polymorphisms and the metabolic syndrome, or between AMI patients and controls. The MC4R-associated TT genotype occurred more frequently in patients with lower triglyceride levels (p = 0.024), while the adiponectin 45 TT genotype occur

SUBMITTER: Ranjith N 

PROVIDER: S-EPMC3736384 | biostudies-literature | 2011 Jan-Feb

REPOSITORIES: biostudies-literature