Ontology highlight
ABSTRACT:
SUBMITTER: Giraudo CG
PROVIDER: S-EPMC3736854 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20090101 5913
Membrane fusion between vesicles and target membranes involves the zippering of a four-helix bundle generated by constituent helices derived from target- and vesicle-soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). In neurons, the protein complexin clamps otherwise spontaneous fusion by SNARE proteins, allowing neurotransmitters and other mediators to be secreted when and where they are needed as this clamp is released. The membrane-proximal accessory helix of com ...[more]