Global eradication rates for Helicobacter pylori infection: systematic review and meta-analysis of sequential therapy.

ABSTRACT:

Objective

To do a systematic review and meta-analysis of studies comparing sequential therapy for eradication of Helicobacter pylori with pre-existing and new therapies, thus providing a glimpse of eradication success worldwide.

Design

Systematic review and meta-analysis.

Data sources

Medline, Embase, and Cochrane Central Register of Controlled Trials up to May 2013; abstract books of major European, American, and Asian gastroenterological meetings.

Study selection

Randomised controlled trials in previously untreated adults, in which sequential therapy was compared with a pre-existing or new therapy.

Results

46 randomised controlled trials were reviewed and analysed. 5666 patients were randomised to sequential therapy and 7866 to other (established and n

SUBMITTER: Gatta L 

PROVIDER: S-EPMC3736972 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature