Associations between serotonin transporter gene polymorphisms and heat pain perception in adults with chronic pain.

ABSTRACT:

Background

The triallelic serotonin transporter gene linked polymorphic region (5-HTTLPR) has been associated with alterations in thermal pain perception. The primary aim of this study was to investigate the associations between heat pain (HP) perception and the triallelic 5-HTTLPR in a large cohort of adults with chronic pain.

Methods

The cohort included 277 adults with chronic pain who met inclusion criteria, and were consecutively admitted to an outpatient pain rehabilitation program from March 2009 through March 2010. Individuals were genotyped for the triallelic 5-HTTLPR (including rs25531) and categorized as high, intermediate, or low expressors of the serotonin transporter. Standardized measures of HP perception were obtained using a validated quantitative sensory tes

SUBMITTER: Hooten WM 

PROVIDER: S-EPMC3737051 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature