Developmental changes in the transcriptome of the rat choroid plexus in relation to neuroprotection.

ABSTRACT:

Background

The choroid plexuses are the interface between the blood and the cerebrospinal fluid (CSF) contained within the ventricular spaces of the central nervous system. The tight junctions linking adjacent cells of the choroidal epithelium create a physical barrier to paracellular movement of molecules. Multispecific efflux transporters as well as drug-metabolizing and antioxidant enzymes functioning in these cells contribute to a metabolic barrier. These barrier properties reflect a neuroprotective function of the choroid plexus. The choroid plexuses develop early during embryogenesis and provide pivotal control of the internal environment throughout development when the brain is especially vulnerable to toxic insults. Perinatal injuries like hypoxia and trauma, and exposure t

SUBMITTER: Kratzer I 

PROVIDER: S-EPMC3737068 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature