Api5 contributes to E2F1 control of the G1/S cell cycle phase transition.

ABSTRACT:

Background

The E2f transcription factor family has a pivotal role in controlling the cell fate in general, and in particular cancer development, by regulating the expression of several genes required for S phase entry and progression through the cell cycle. It has become clear that the transcriptional activation of at least one member of the family, E2F1, can also induce apoptosis. An appropriate balance of positive and negative regulators appears to be necessary to modulate E2F1 transcriptional activity, and thus cell fate.

Methodology/principal findings

In this report, we show that Api5, already known as a regulator of E2F1 induced-apoptosis, is required for the E2F1 transcriptional activation of G1/S transition genes, and consequently, for cell cycle progression and cell

SUBMITTER: Garcia-Jove Navarro M 

PROVIDER: S-EPMC3737092 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature