Interactions between alcohol and the antiretroviral medications ritonavir or efavirenz.

ABSTRACT:

Objective

Alcohol abuse occurs frequently in those with human immunodeficiency virus (HIV) infection. Alcohol has been linked to poor response to HIV treatment and more rapid progression of HIV. One possible contributor to such observations is drug interactions between alcohol and antiretroviral (ARV) medications. This study examined drug interactions between antiretroviral therapies (ARTs) containing either efavirenz or ritonavir with alcohol.

Methods

Human immunodeficiency virus-infected individuals not currently receiving ARTs participated in a randomized, double-blind, placebo-controlled study in which alcohol (or placebo) was administered and followed by blood sampling for pharmacokinetics, subjective, cardiovascular, and neuropsychological responses obtained at predete

SUBMITTER: McCance-Katz EF 

PROVIDER: S-EPMC3737351 | biostudies-literature | 2013 Jul-Aug

REPOSITORIES: biostudies-literature