Increased expression of factor XIII-A in patients with chronic rhinosinusitis with nasal polyps.

ABSTRACT:

Background

Profound edema or formation of a pseudocyst containing plasma proteins is a prominent characteristic of nasal polyps (NP). However, the mechanisms underlying NP retention of plasma proteins in the submucosa remain unclear. Recently, we reported that impairment of fibrinolysis causes excessive fibrin deposition in NP and this might be involved in the retention of plasma proteins. Although the coagulation cascade plays a critical role in fibrin clot formation at extravascular sites, the expression and role of coagulation factors in NP remain unclear.

Objective

The objective of this study was to investigate the expression of coagulation factors in patients with chronic rhinosinusitis (CRS).

Methods

Sinonasal tissues were collected from patients with CRS and co

SUBMITTER: Takabayashi T 

PROVIDER: S-EPMC3737402 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature