A novel interplay between the Fanconi anemia core complex and ATR-ATRIP kinase during DNA cross-link repair.

ABSTRACT: When DNA replication is stalled at sites of DNA damage, a cascade of responses is activated in the cell to halt cell cycle progression and promote DNA repair. A pathway initiated by the kinase Ataxia teleangiectasia and Rad3 related (ATR) and its partner ATR interacting protein (ATRIP) plays an important role in this response. The Fanconi anemia (FA) pathway is also activated following genomic stress, and defects in this pathway cause a cancer-prone hematologic disorder in humans. Little is known about how these two pathways are coordinated. We report here that following cellular exposure to DNA cross-linking damage, the FA core complex enhances binding and localization of ATRIP within damaged chromatin. In cells lacking the core complex, ATR-mediated phosphorylation of two functional resp

SUBMITTER: Tomida J 

PROVIDER: S-EPMC3737553 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature