Discovering high-resolution patterns of differential DNA methylation that correlate with gene expression changes.

ABSTRACT: Methylation of the CpG-rich region (CpG island) overlapping a gene's promoter is a generally accepted mechanism for silencing expression. While recent technological advances have enabled measurement of DNA methylation and expression changes genome-wide, only modest correlations between differential methylation at gene promoters and expression have been found. We hypothesize that stronger associations are not observed because existing analysis methods oversimplify their representation of the data and do not capture the diversity of existing methylation patterns. Recently, other patterns such as CpG island shore methylation and long partially hypomethylated domains have also been linked with gene silencing. Here, we detail a new approach for discovering differential methylation patterns asso

SUBMITTER: Vanderkraats ND 

PROVIDER: S-EPMC3737560 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature