MicroRNA profiles classify papillary renal cell carcinoma subtypes.

ABSTRACT:

Background

Besides the conventional clear-cell renal cell carcinoma (ccRCC), papillary RCC (pRCC) is the second most common renal malignancy. Papillary RCCs can further be subdivided into two distinct subtypes. Although a clinical relevance of pRCC subtyping has been shown, little is known about the molecular characteristics of both pRCC subtypes.

Methods

We performed microarray-based microRNA (miRNA) expression profiling of primary ccRCC and pRCC cases. A subset of miRNAs was identified and used to establish a classification model for ccRCC, pRCC types 1 and 2 and normal tissue. Furthermore, we performed gene set enrichment analysis with the predicted miRNA target genes.

Results

Only five miRNAs (miR-145, -200c, -210, -502-3p and let-7c) were sufficient to identify t

SUBMITTER: Wach S 

PROVIDER: S-EPMC3738121 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature