Modulation of the current signatures of DNA abasic site adducts in the α-hemolysin ion channel.

ABSTRACT: Electrical current signatures of DNA adducts were investigated during immobilization of strands inside the membrane-bound α-hemolysin ion channel. The current blockages produced by these adducts were found to depend on both size and shape, providing insights into the DNA-protein interactions and the size limitation of bulky adducts to be translocated.

SUBMITTER: An N 

PROVIDER: S-EPMC3738171 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature