A viral-human interactome based on structural motif-domain interactions captures the human infectome.

ABSTRACT: Protein interactions between a pathogen and its host are fundamental in the establishment of the pathogen and underline the infection mechanism. In the present work, we developed a single predictive model for building a host-viral interactome based on the identification of structural descriptors from motif-domain interactions of protein complexes deposited in the Protein Data Bank (PDB). The structural descriptors were used for searching, in a database of protein sequences of human and five clinically important viruses; therefore, viral and human proteins sharing a descriptor were predicted as interacting proteins. The analysis of the host-viral interactome allowed to identify a set of new interactions that further explain molecular mechanism associated with viral infections and showed tha

SUBMITTER: Segura-Cabrera A 

PROVIDER: S-EPMC3738538 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature