A population model of folate-mediated one-carbon metabolism.

ABSTRACT:

Background

Previous mathematical models for hepatic and tissue one-carbon metabolism have been combined and extended to include a blood plasma compartment. We use this model to study how the concentrations of metabolites that can be measured in the plasma are related to their respective intracellular concentrations.

Methods

The model consists of a set of ordinary differential equations, one for each metabolite in each compartment, and kinetic equations for metabolism and for transport between compartments. The model was validated by comparison to a variety of experimental data such as the methionine load test and variation in folate intake. We further extended this model by introducing random and systematic variation in enzyme activity. OUTCOMES AND CONCLUSIONS: A database o

SUBMITTER: Duncan TM 

PROVIDER: S-EPMC3738981 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature