Antiglaucomatous effects of the activation of intrinsic Angiotensin-converting enzyme 2.

ABSTRACT:

Purpose

To evaluate the effects of the activation of endogenous angiotensin-converting enzyme 2 (ACE2) using the compound diminazene aceturate (DIZE) in an experimental model of glaucoma in Wistar rats.

Methods

DIZE (1 mg/kg) was administered daily, either systemically or topically, and the IOP was measured weekly. To examine the role of the Mas receptor in the effects of DIZE, the Ang-(1-7) antagonist A-779 was co-administered. Drainage of the aqueous humor was evaluated by using scintigraphy. The analysis of ACE2 expression by immunohistochemistry and the counting of retinal ganglion cells (RGCs) were performed in histologic sections. Additionally, the nerve fiber structure was evaluated by transmission electron microscopy.

Results

The systemic administration and to

SUBMITTER: Foureaux G 

PROVIDER: S-EPMC3739491 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature