Pathway analysis using genome-wide association study data for coronary restenosis--a potential role for the PARVB gene.

ABSTRACT:

Background

Coronary restenosis after percutaneous coronary intervention (PCI) still remains a significant limitation of the procedure. The causative mechanisms of restenosis have not yet been fully identified. The goal of the current study was to perform gene-set analysis of biological pathways related to inflammation, proliferation, vascular function and transcriptional regulation on coronary restenosis to identify novel genes and pathways related to this condition.

Methods

The GENetic DEterminants of Restenosis (GENDER) databank contains genotypic data of 556,099SNPs of 295 cases with restenosis and 571 matched controls. Fifty-four pathways, related to known restenosis-related processes, were selected. Gene-set analysis was performed using PLINK, GRASS and ALIGATOR softwar

SUBMITTER: Verschuren JJ 

PROVIDER: S-EPMC3739784 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature