Long lasting protein synthesis- and activity-dependent spine shrinkage and elimination after synaptic depression.

ABSTRACT: Neuronal circuits modify their response to synaptic inputs in an experience-dependent fashion. Increases in synaptic weights are accompanied by structural modifications, and activity dependent, long lasting growth of dendritic spines requires new protein synthesis. When multiple spines are potentiated within a dendritic domain, they show dynamic structural plasticity changes, indicating that spines can undergo bidirectional physical modifications. However, it is unclear whether protein synthesis dependent synaptic depression leads to long lasting structural changes. Here, we investigate the structural correlates of protein synthesis dependent long-term depression (LTD) mediated by metabotropic glutamate receptors (mGluRs) through two-photon imaging of dendritic spines on hippocampal pyrami

SUBMITTER: Ramiro-Cortes Y 

PROVIDER: S-EPMC3739806 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature