Reduced functional connectivity within and between 'social' resting state networks in autism spectrum conditions.

ABSTRACT: Individuals with autism spectrum conditions (ASC) have difficulties in social interaction and communication, which is reflected in hypoactivation of brain regions engaged in social processing, such as medial prefrontal cortex (mPFC), amygdala and insula. Resting state studies in ASC have identified reduced connectivity of the default mode network (DMN), which includes mPFC, suggesting that other resting state networks incorporating 'social' brain regions may also be abnormal. Using seed-based connectivity and group independent component analysis (ICA) approaches, we looked at resting functional connectivity in ASC between specific 'social' brain regions, as well as within and between whole networks incorporating these regions. We found reduced functional connectivity within the DMN in indi

SUBMITTER: von dem Hagen EA 

PROVIDER: S-EPMC3739917 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature