IFNγ influences type I interferon response and susceptibility to Theiler's virus-induced demyelinating disease.

ABSTRACT: Theiler's murine encephalomyelitis virus (TMEV) induces a demyelinating disease in susceptible SJL mice that has similarities to multiple sclerosis in humans. TMEV infection of susceptible mice leads to a persistent virus infection of the central nervous system (CNS), which promotes the development of demyelinating disease associated with an inflammatory immune response in the CNS. TMEV infection of resistant C57BL6 mice results in viral clearance without development of demyelinating disease. Interestingly, TMEV infection of resistant mice deficient in IFNγ leads to a persistent virus infection in the CNS and development of demyelinating disease. We have previously shown that the innate immune response affects development of TMEV- induced demyelinating disease, thus we wanted to determine

SUBMITTER: Bowen JL 

PROVIDER: S-EPMC3739950 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature