Characterization of cytotoxic T lymphocyte function after foot-and-mouth disease virus infection and vaccination.

ABSTRACT: The induction of neutralizing antibodies specific for foot-and-mouth disease virus (FMDV) has been the central goal of vaccination efforts against this economically important disease of cloven-hoofed animals. Although these efforts have yielded much success, challenges remain, including little cross-serotype protection and inadequate duration of immunity. Commonly, viral infections are characterized by induction of cytotoxic T lymphocytes (CTL), yet the function of CTL in FMDV immunity is poorly defined. We developed an assay for detection of CTL specific for FMDV and reported that a modified adenovirus-vectored FMDV vaccine could induce CTL activity. This allowed us to determine whether FMDV-specific CTL responses are induced during infection and to test further whether vaccine-induced CT

SUBMITTER: Patch JR 

PROVIDER: S-EPMC3739958 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature