Asymmetric cell division of T cells upon antigen presentation uses multiple conserved mechanisms.

ABSTRACT: Asymmetric cell division is a potential means by which cell fate choices during an immune response are orchestrated. Defining the molecular mechanisms that underlie asymmetric division of T cells is paramount for determining the role of this process in the generation of effector and memory T cell subsets. In other cell types, asymmetric cell division is regulated by conserved polarity protein complexes that control the localization of cell fate determinants and spindle orientation during division. We have developed a tractable, in vitro model of naive CD8(+) T cells undergoing initial division while attached to dendritic cells during Ag presentation to investigate whether similar mechanisms might regulate asymmetric division of T cells. Using this system, we show that direct interactions w

SUBMITTER: Oliaro J 

PROVIDER: S-EPMC3739982 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature