A high-fat diet supplemented with fish oil improves metabolic features associated with type 2 diabetes.

ABSTRACT:

Objective

The goal of this study was to investigate the effects of a high-fat diet supplemented with fish oil or olive oil, fed to C57BL/6J mice for an extended period, on metabolic features associated with type 2 diabetes.

Methods

Mice were fed one of four diets for 30 wk: a low-fat diet, a high-fat diet supplemented with lard, a high-fat diet supplemented with fish oil, or a high-fat diet supplemented with olive oil. Phenotypic and metabolic analysis were determined at 15 and 25 to 30 wk, thereby providing comparative analysis for weight gain, energy consumption, fat distribution, glucose and insulin tolerance, and hepatic/plasma lipid analysis.

Results

Mice fed a high-fat diet supplemented with fish oil had improved glucose tolerance after an extended period compar

SUBMITTER: Jelinek D 

PROVIDER: S-EPMC3740005 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature