Increased coronary atherosclerotic plaque vulnerability by coronary computed tomography angiography in HIV-infected men.

ABSTRACT:

Objective

Among HIV-infected patients, high rates of myocardial infarction (MI) and sudden cardiac death have been observed. Exploring potential underlying mechanisms, we used multidetector spiral coronary computed tomography angiography (coronary CTA) to compare atherosclerotic plaque morphology in HIV-infected patients and non-HIV-infected controls.

Methods

Coronary atherosclerotic plaques visualized by CTA in HIV-infected (101) and non-HIV-infected (41) men without clinically apparent heart disease matched on cardiovascular risk factors were analyzed for three vulnerability features: low attenuation, positive remodeling, and spotty calcification.

Results

Ninety-five percent of HIV-infected patients were receiving ART (median duration 7.9 years) and had well control

SUBMITTER: Zanni MV 

PROVIDER: S-EPMC3740057 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature