Kinome Render: a stand-alone and web-accessible tool to annotate the human protein kinome tree.

ABSTRACT: Human protein kinases play fundamental roles mediating the majority of signal transduction pathways in eukaryotic cells as well as a multitude of other processes involved in metabolism, cell-cycle regulation, cellular shape, motility, differentiation and apoptosis. The human protein kinome contains 518 members. Most studies that focus on the human kinome require, at some point, the visualization of large amounts of data. The visualization of such data within the framework of a phylogenetic tree may help identify key relationships between different protein kinases in view of their evolutionary distance and the information used to annotate the kinome tree. For example, studies that focus on the promiscuity of kinase inhibitors can benefit from the annotations to depict binding affinities acr

SUBMITTER: Chartier M 

PROVIDER: S-EPMC3740139 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature