Rapid quantitative pharmacodynamic imaging by a novel method: theory, simulation testing and proof of principle.

ABSTRACT: Pharmacological challenge imaging has mapped, but rarely quantified, the sensitivity of a biological system to a given drug. We describe a novel method called rapid quantitative pharmacodynamic imaging. This method combines pharmacokinetic-pharmacodynamic modeling, repeated small doses of a challenge drug over a short time scale, and functional imaging to rapidly provide quantitative estimates of drug sensitivity including EC 50 (the concentration of drug that produces half the maximum possible effect). We first test the method with simulated data, assuming a typical sigmoidal dose-response curve and assuming imperfect imaging that includes artifactual baseline signal drift and random error. With these few assumptions, rapid quantitative pharmacodynamic imaging reliably estimates EC 50 fro

SUBMITTER: Black KJ 

PROVIDER: S-EPMC3740141 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature