Bioinspired total synthesis of katsumadain A by organocatalytic enantioselective 1,4-conjugate addition.

ABSTRACT: Katsumadain A, a naturally occurring influenza virus neuraminidase (NA) inhibitor, was synthesized by using a bioinspired, organocatalytic enantioselective 1,4-conjugate addition of styryl-2-pyranone with cinnamaldehyde, followed by a tandem Horner-Wadsworth-Emmons/oxa Michael addition.

SUBMITTER: Wang Y 

PROVIDER: S-EPMC3740603 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature