Candidate gene linkage approach to identify DNA variants that predispose to preterm birth.

ABSTRACT:

Background

The aim of this study was to identify genetic variants contributing to preterm birth (PTB) using a linkage candidate gene approach.

Methods

We studied 99 single-nucleotide polymorphisms (SNPs) for 33 genes in 257 families with PTBs segregating. Nonparametric and parametric analyses were used. Premature infants and mothers of premature infants were defined as affected cases in independent analyses.

Results

Analyses with the infant as the case identified two genes with evidence of linkage: CRHR1 (P = 0.0012) and CYP2E1 (P = 0.0011). Analyses with the mother as the case identified four genes with evidence of linkage: ENPP1 (P = 0.003), IGFBP3 (P = 0.006), DHCR7 (P = 0.009), and TRAF2 (P = 0.01). DNA sequence analysis of the coding exons and splice sites for CR

SUBMITTER: Bream EN 

PROVIDER: S-EPMC3740714 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature