Increased superoxide and endothelial NO synthase uncoupling in blood vessels of Bmal1-knockout mice.

ABSTRACT:

Rationale

Disruption of the circadian clock in mice produces vascular dysfunction as evidenced by impairments in endothelium-dependent signaling, vasomotion, and blood vessel remodeling. Although the altered function of endothelial NO synthase and the overproduction of reactive oxygen species are central to dysfunction of the endothelium, to date, the impact of the circadian clock on endothelial NO synthase coupling and vascular reactive oxygen species production is not known.

Objective

The goals of the present study were to determine whether deletion of a critical component of the circadian clock, Bmal1, can influence endothelial NO synthase coupling and reactive oxygen species levels in arteries from Bmal1-knockout (KO) mice.

Methods and results

Endothelial function

SUBMITTER: Anea CB 

PROVIDER: S-EPMC3740771 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature