Clear cell renal cell carcinoma associated microRNA expression signatures identified by an integrated bioinformatics analysis.

ABSTRACT:

Background

Clear cell renal cell carcinoma (ccRCC) represents the most invasive and common adult kidney neoplasm. Mounting evidence suggests that microRNAs (miRNAs) are important regulators of gene expression. But their function in tumourigenesis in this tumour type remains elusive. With the development of high throughput technologies such as microarrays and NGS, aberrant miRNA expression has been widely observed in ccRCC. Systematic and integrative analysis of multiple microRNA expression datasets may reveal potential mechanisms by which microRNAs contribute to ccRCC pathogenesis.

Methods

We collected 5 public microRNA expression datasets in ccRCC versus non-matching normal renal tissues from GEO database and published literatures. We analyzed these data sets with an integr

SUBMITTER: Chen J 

PROVIDER: S-EPMC3740788 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature