Intrinsic gray-matter connectivity of the brain in adults with autism spectrum disorder.

ABSTRACT: Autism spectrum disorders (ASD) are a group of neurodevelopmental conditions that are accompanied by atypical brain connectivity. So far, in vivo evidence for atypical structural brain connectivity in ASD has mainly been based on neuroimaging studies of cortical white matter. However, genetic studies suggest that abnormal connectivity in ASD may also affect neural connections within the cortical gray matter. Such intrinsic gray-matter connections are inherently more difficult to describe in vivo but may be inferred from a variety of surface-based geometric features that can be measured using magnetic resonance imaging. Here, we present a neuroimaging study that examines the intrinsic cortico-cortical connectivity of the brain in ASD using measures of "cortical separation distances" to asse

SUBMITTER: Ecker C 

PROVIDER: S-EPMC3740833 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature