Ontology highlight
ABSTRACT:
SUBMITTER: Zaydman MA
PROVIDER: S-EPMC3740903 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Zaydman Mark A MA Silva Jonathan R JR Delaloye Kelli K Li Yang Y Liang Hongwu H Larsson H Peter HP Shi Jingyi J Cui Jianmin J
Proceedings of the National Academy of Sciences of the United States of America 20130716 32
Voltage-gated ion channels generate dynamic ionic currents that are vital to the physiological functions of many tissues. These proteins contain separate voltage-sensing domains, which detect changes in transmembrane voltage, and pore domains, which conduct ions. Coupling of voltage sensing and pore opening is critical to the channel function and has been modeled as a protein-protein interaction between the two domains. Here, we show that coupling in Kv7.1 channels requires the lipid phosphatidy ...[more]