Dataset Information
Genome-wide methylation profiling demonstrates hypermethylation in maternal leukocyte DNA in preeclamptic compared to normotensive pregnancies.
Ontology highlight
ABSTRACT:
SUBMITTER: White WM
PROVIDER: S-EPMC3741019 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Publications
Genome-wide methylation profiling demonstrates hypermethylation in maternal leukocyte DNA in preeclamptic compared to normotensive pregnancies.
Hypertension in pregnancy 20130619 3
<h4>Objective</h4>To compare genome-wide methylation profiles in maternal leukocyte DNA between normotensive and preeclamptic pregnant women at delivery.<h4>Methods</h4>Age, body mass index matched case-control comparison of methylation at 27,578 cytosine-- guanine sites in 14,495 genes in maternal leukocyte DNA in women with preeclampsia (PE; n = 14) and normotensive controls (n = 14).<h4>Results</h4>PE was associated with widespread differential methylation favoring hypermethylation. Pathway a ...[more]
