Obesity impairs lymphatic fluid transport and dendritic cell migration to lymph nodes.

ABSTRACT:

Introduction

Obesity is a major cause of morbidity and mortality resulting in pathologic changes in virtually every organ system. Although the cardiovascular system has been a focus of intense study, the effects of obesity on the lymphatic system remain essentially unknown. The purpose of this study was to identify the pathologic consequences of diet induced obesity (DIO) on the lymphatic system.

Methods

Adult male wild-type or RAG C57B6-6J mice were fed a high fat (60%) or normal chow diet for 8-10 weeks followed by analysis of lymphatic transport capacity. In addition, we assessed migration of dendritic cells (DCs) to local lymph nodes, lymph node architecture, and lymph node cellular make up.

Results

High fat diet resulted in obesity in both wild-type and RAG mice

SUBMITTER: Weitman ES 

PROVIDER: S-EPMC3741281 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature