Neuroprotective effects of cognitive enhancement therapy against gray matter loss in early schizophrenia: results from a 2-year randomized controlled trial.

ABSTRACT:

Context

Cognitive rehabilitation has shown efficacy in improving cognition in patients with schizophrenia but the underlying neurobiologic changes that occur during these treatments and support cognitive improvement are not well known.

Objective

To examine differential changes in brain morphology in early course schizophrenia during cognitive rehabilitation vs supportive therapy.

Design

Randomized controlled trial.

Setting

An outpatient research clinic at a university-based medical center that provides comprehensive care services for patients with severe mental illness.

Patients

A total of 53 symptomatically stable but cognitively disabled outpatients in the early course of schizophrenia or schizoaffective disorder.

Interventions

A 2-year trial wi

SUBMITTER: Eack SM 

PROVIDER: S-EPMC3741671 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature