Mitochondrial targeted antioxidant Peptide ameliorates hypertensive cardiomyopathy.

ABSTRACT:

Objectives

We investigated the effect of reducing mitochondrial oxidative stress by the mitochondrial-targeted antioxidant peptide SS-31 in hypertensive cardiomyopathy.

Background

Oxidative stress has been implicated in hypertensive cardiovascular diseases. Mitochondria and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase have been proposed as primary sites of reactive oxygen species (ROS) generation.

Methods

The mitochondrial targeted antioxidant peptide SS-31 was used to determine the role of mitochondrial oxidative stress in angiotensin II (Ang)-induced cardiomyopathy as well as in Gαq overexpressing mice with heart failure.

Results

Ang induces mitochondrial ROS in neonatal cardiomyocytes, which is prevented by SS-31, but not the nontargeted antio

SUBMITTER: Dai DF 

PROVIDER: S-EPMC3742010 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature