Brain fMRI reactivity to smoking-related images before and during extended smoking abstinence.

ABSTRACT: Reactivity to smoking-related cues may play a role in the maintenance of smoking behavior and may change depending on smoking status. Whether smoking cue-related functional MRI (fMRI) reactivity differs between active smoking and extended smoking abstinence states currently is unknown. We used fMRI to measure brain reactivity in response to smoking-related versus neutral images in 13 tobacco-dependent subjects before a smoking cessation attempt and again during extended smoking abstinence (52 +/- 11 days) aided by nicotine replacement therapy. Prequit smoking cue induced fMRI activity patterns paralleled those reported in prior smoking cue reactivity fMRI studies. Greater fMRI activity was detected during extended smoking abstinence than during the pre-quit [corrected] assessment subcortic

SUBMITTER: Janes AC 

PROVIDER: S-EPMC3742373 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature