MYRF is a membrane-associated transcription factor that autoproteolytically cleaves to directly activate myelin genes.

ABSTRACT: The myelination of axons is a crucial step during vertebrate central nervous system (CNS) development, allowing for rapid and energy efficient saltatory conduction of nerve impulses. Accordingly, the differentiation of oligodendrocytes, the myelinating cells of the CNS, and their expression of myelin genes are under tight transcriptional control. We previously identified a putative transcription factor, Myelin Regulatory Factor (Myrf), as being vital for CNS myelination. Myrf is required for the generation of CNS myelination during development and also for its maintenance in the adult. It has been controversial, however, whether Myrf directly regulates transcription, with reports of a transmembrane domain and lack of nuclear localization. Here we show that Myrf is a membrane-associated tra

SUBMITTER: Bujalka H 

PROVIDER: S-EPMC3742440 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature