Metabolic and endocrine correlates of cognitive function in healthy young women.

ABSTRACT:

Objective

Obesity has been associated with cognitive decline in longitudinal studies of older individuals. We hypothesized that the cognitive sequelae of obesity may be detectable in the reproductive years. In addition, we explored the hypothesis that these associations may be mediated by the hormonal milieu.

Design and methods

Of 49 young healthy lean and overweight women aged 20-45, we investigated the association between performance on a battery of cognitive tests, body composition parameters [body mass index, total fat, abdominal (visceral, subcutaneous, and total) adipose tissue, and muscle], and hormone levels (insulin, adiponectin, leptin, insulin-like growth factor 1 (IGF-1), estrogen, testosterone, and vitamin D).

Results

We found a significant negative assoc

SUBMITTER: Bove RM 

PROVIDER: S-EPMC3742554 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature