Serum leptin and adiponectin levels and risk of renal cell carcinoma.

ABSTRACT:

Objective

The incidence of renal cell carcinoma (RCC) has increased rapidly in the U.S., particularly among African Americans. Despite a well-established link between obesity and RCC, the mechanism through which obesity increases cancer risk has yet to be established. Adipokines, such as leptin and adiponectin, may link obesity and cancer, with different quantitative effects by race.

Design and methods

We evaluated the association between leptin and adiponectin concentrations and RCC risk among Caucasians (581 cases, 558 controls) and African Americans (187 cases, 359 controls) in a case-control study conducted in Detroit and Chicago. Odds ratios (ORs) and 95% confidence intervals (95%CIs) were estimated using unconditional logistic regression.

Results

Among controls,

SUBMITTER: Liao LM 

PROVIDER: S-EPMC3742622 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature