Ontology highlight
ABSTRACT:
SUBMITTER: Vinukonda G
PROVIDER: S-EPMC3742687 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Experimental neurology 20130306
Intraventricular hemorrhage (IVH) results in white matter injury and hydrocephalus in premature infants. Chondroitin sulfate proteoglycans (CSPGs)-neuorcan, brevican, versican, aggrecan and phosphacan-are unregulated in the extracellular matrix after brain injury, and their degradation enhances plasticity of the brain. Therefore, we hypothesized that CSPG levels were elevated in the forebrain of premature infants with IVH and that in vivo degradation of CSPGs would enhance maturation of oligoden ...[more]