Mechanisms of seizure propagation in 2-dimensional centre-surround recurrent networks.

ABSTRACT: Understanding how seizures spread throughout the brain is an important problem in the treatment of epilepsy, especially for implantable devices that aim to avert focal seizures before they spread to, and overwhelm, the rest of the brain. This paper presents an analysis of the speed of propagation in a computational model of seizure-like activity in a 2-dimensional recurrent network of integrate-and-fire neurons containing both excitatory and inhibitory populations and having a difference of Gaussians connectivity structure, an approximation to that observed in cerebral cortex. In the same computational model network, alternative mechanisms are explored in order to simulate the range of seizure-like activity propagation speeds (0.1-100 mm/s) observed in two animal-slice-based models of epil

SUBMITTER: Hall D 

PROVIDER: S-EPMC3742758 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature