Systemic administration of follistatin288 increases muscle mass and reduces fat accumulation in mice.

ABSTRACT: The present study describes the physiological response associated with daily subcutaneous injection of mice with recombinant follistatin288. This systemic administration of follistatin288 increases the follistatin levels in serum, indicating that the protein enters the circulation. The data suggest that a dose-dependent increase in body lean mass also occurs, together with an increase in muscle mass, possibly as a result of an increase in the size of the muscle fibers. After thirteen weeks of treatment, metabolic changes were observed; additionally, the switching of muscle fiber types was also apparent through myosin heavy chain remodeling, implying that changes are occurring at the molecular level. Furthermore, an increase in the muscle mass was associated with a significant decrease in t

SUBMITTER: Gangopadhyay SS 

PROVIDER: S-EPMC3743061 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature