Elevated left mid-frontal cortical activity prospectively predicts conversion to bipolar I disorder.

ABSTRACT: Bipolar disorder is characterized by a hypersensitivity to reward-relevant cues and a propensity to experience an excessive increase in approach-related affect, which may be reflected in hypo/manic symptoms. The present study examined the relationship between relative left-frontal electroencephalographic (EEG) activity, a proposed neurophysiological index of approach-system sensitivity and approach/reward-related affect, and bipolar course and state-related variables. Fifty-eight individuals with cyclothymia or bipolar II disorder and 59 healthy control participants with no affective psychopathology completed resting EEG recordings. Alpha power was obtained and asymmetry indices computed for homologous electrodes. Bipolar spectrum participants were classified as being in a major/minor depr

SUBMITTER: Nusslock R 

PROVIDER: S-EPMC3743092 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature