Paradoxical association of enhanced cholesterol efflux with increased incident cardiovascular risks.

ABSTRACT:

Objective

Diminished cholesterol efflux activity of apolipoprotein B (apoB)-depleted serum is associated with prevalent coronary artery disease, but its prognostic value for incident cardiovascular events is unclear. We investigated the relationship of cholesterol efflux activity with both prevalent coronary artery disease and incident development of major adverse cardiovascular events (death, myocardial infarction, or stroke).

Approach and results

Cholesterol efflux activity from free cholesterol-enriched macrophages was measured in 2 case-control cohorts: (1) an angiographic cohort (n=1150) comprising stable subjects undergoing elective diagnostic coronary angiography and (2) an outpatient cohort (n=577). Analysis of media from cholesterol efflux assays revealed that the h

SUBMITTER: Li XM 

PROVIDER: S-EPMC3743250 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature