Thr698Thr (nt2369) polymorphism on CACNA1A gene and head pain severity in familial migraine.

ABSTRACT:

Background

Migraine is a common neurological disorder with a significant genetic component. Less information is known about the contribution of minor genetic variations, such as single nucleotide polymorphism (SNP) on the migraine process. In the present study, we aim to investigate the role of CACNA1A gene polymorphism on severity and related factors in family positive migraine patients.

Materials and methods

We included 74 common migraine patients consequently. Headache severity was evaluated according to Headache Impact Test (HIT6) questionnaire and quality of life of patients was investigated according to MSQ (Migraine-Specific Quality of Life Questionnaire v2.1) questionnaire. Thirty patients with positive family history of migraine were selected and sequencing analysis

SUBMITTER: Meamar R 

PROVIDER: S-EPMC3743310 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature