Initial trophic vs full enteral feeding in patients with acute lung injury: the EDEN randomized trial.

ABSTRACT:

Context

The amount of enteral nutrition patients with acute lung injury need is unknown.

Objective

To determine if initial lower-volume trophic enteral feeding would increase ventilator-free days and decrease gastrointestinal intolerances compared with initial full enteral feeding.

Design, setting, and participants

The EDEN study, a randomized, open-label, multicenter trial conducted from January 2, 2008, through April 12, 2011. Participants were 1000 adults within 48 hours of developing acute lung injury requiring mechanical ventilation whose physicians intended to start enteral nutrition at 44 hospitals in the National Heart, Lung, and Blood Institute ARDS Clinical Trials Network.

Interventions

Participants were randomized to receive either trophic or full en

SUBMITTER: National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network 

PROVIDER: S-EPMC3743415 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature