Immunocytochemical evidence for SNARE protein-dependent transmitter release from guinea pig horizontal cells.

ABSTRACT: Horizontal cells are lateral interneurons that participate in visual processing in the outer retina but the cellular mechanisms underlying transmitter release from these cells are not fully understood. In non-mammalian horizontal cells, GABA release has been shown to occur by a non-vesicular mechanism. However, recent evidence in mammalian horizontal cells favors a vesicular mechanism as they lack plasmalemmal GABA transporters and some soluble NSF attachment protein receptor (SNARE) core proteins have been identified in rodent horizontal cells. Moreover, immunoreactivity for GABA and the molecular machinery to synthesize GABA have been found in guinea pig horizontal cells, suggesting that if components of the SNARE complex are expressed they could contribute to the vesicular release of GA

SUBMITTER: Lee H 

PROVIDER: S-EPMC3743676 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature