Insulin-like growth factor-1 protects ischemic murine myocardium from ischemia/reperfusion associated injury.

ABSTRACT:

Introduction

Ischemia/reperfusion occurs in myocardial infarction, cardiac dysfunction during sepsis, cardiac transplantation and coronary artery bypass grafting, and results in injury to the myocardium. Although reperfusion injury is related to the nature and duration of ischemia, it is also a separate entity that may jeopardize viable cells and ultimately may impair cardiac performance once ischemia is resolved and the organ heals.

Method

The present study was conducted in an ex vivo murine model of myocardial ischemia/reperfusion injury. After 20 min of ischemia, isolated hearts were perfused for up to 2 hours with solution (modified Kreb's) only, solution plus insulin-like growth factor (IGF)-1, or solution plus tumor necrosis factor (TNF)-alpha. Cardiac contractility wa

SUBMITTER: Davani EY 

PROVIDER: S-EPMC374373 | biostudies-literature | 2003 Dec

REPOSITORIES: biostudies-literature