ACTH- and cortisol-associated neutrophil modulation in coronary artery disease patients undergoing stent implantation.

ABSTRACT:

Background

Psychosocial stress and activation of neutrophil granulocytes are increasingly recognized as major risk factors of coronary artery disease (CAD), but the possible relationship of these two factors in CAD patients is largely unexplored. Activation of neutrophils was reported to be associated with stenting; however, the issue of neutrophil state in connection with percutaneous coronary intervention (PCI) is incompletely understood from the aspect of stress and its hypothalamic-pituitary-adrenal axis (HPA) background. Thus, we aimed to study cortisol- and ACTH-associated changes in granulocyte activation in patients undergoing PCI.

Methodology/principal findings

Blood samples of 21 stable angina pectoris (SAP) and 20 acute coronary syndrome (ACS) patients were collec

SUBMITTER: Keresztes M 

PROVIDER: S-EPMC3743772 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature